Experimental study on lauromacrogol in sclerotherapy of endometrial cyst models
10.3760/cma.j.issn.1004-4477.2013.06.025
- VernacularTitle:介入硬化剂聚桂醇治疗子宫内膜异位囊肿的实验研究
- Author:
Jun ZHOU
;
Jianfu TAN
;
Ruiqiang GUO
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Lauromacrogol;
Endometriosis;
Cysts;
Sclerotherapy
- From:
Chinese Journal of Ultrasonography
2013;(6):535-538
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of the lauromacrogol in sclerosis therapy of endometrial cyst models of SD rat.Methods 45 SD rats were randomly divided into lauromacrogol treatment group,dehydrated alcohol treatment group and physiological saline blank group after being built cysts models.Then corresponding medicine was injected into the cysts,and the changes of pathomorphology and VEGF expression of ectopia endomembrane were observed a week later.Results Microscope observation indicated that endometrial cyst glandular epithelium and gland were inactived by both lauromacrogol and dehydrated alcohol.The effective rate of lauromacrogol group was 87.5％,and that of dehydrated alcohol group was 85.0％.There was no significant difference between these two methods (P =1.000).The ectopia endomembrane glandular organs of physiological saline group were not destructed obviously.Besides,VEGF expression of lauromacrogol and dehydrated alcohol group were lower than physiological saline group (P =0.003 and 0.006).There was no significant difference between VEGF expression of lauromacrogol and dehydrated alcohol group (P =0.926).Conclusions Compared with dehydrated alcohol,lauromacrogol had the same therapeutic effect on sclerosis therapy of endometrial cyst models.
