Relationship of tranexamic acid therapy duration with hidden blood loss after total hip arthroplasty
10.3760/cma.j.issn.1001-8050.2013.06.017
- VernacularTitle:氨甲环酸使用时间与全髋关节置换术隐性失血的临床研究
- Author:
Zheng FU
;
Jian ZHANG
- Publication Type:Journal Article
- Keywords:
Tranexamic acid;
Arthroplasty,replacement,hip;
Femoral neck fractures;
Blood loss,surgical
- From:
Chinese Journal of Trauma
2013;(6):541-544
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the impact of tranexamic acid on visible and hidden blood loss after the preliminary unilateral total hip arthtoplasty (THA).Methods The study involved 60 patients who received primary unilateral THA due to femoral neck fracture from March 2010 to September 2011.They were 18 males and 42 females,at 58 to 86 years of age (average 74.5 years).They were divided into Group A (n =20),not given tranexamic acid,Group B (n =20),given tranexamic acid in operation,Group C (n =20),given tranexamic acid at preoperative one hour according to stratified random method.Total red blood cell loss,visible red blood cell loss,and hidden red blood cell loss in each group were calculated.Results Visible red blood cell loss in Groups A,B,and C was (95.4 ± 17.7) ml,(45.5 ± 11.5) rnl,and (45.3 ± 8.4) ml respectively.Moreover,difference of visible red blood cell loss was significant between Groups A and B (P ＜ 0.05),but insignificant between Groups B and C (P ＞ 0.05).Hidden red blood cell loss in Groups A,B,and C was (322.4 ± 57.7) ml,(203.8 ±46.6) ml,and (137.6 ± 34.7) ml respectively,with significant difference between Groups A and B (P＜0.05) and between Groups B and C (P＜0.05).Conclusions Tranexamic acid reduces the visible and hidden blood loss in primary unilateral THA significantly.While tranexamic acid administered at preoperative one hour gains advantage of less hidden blood loss over the intraoperative administration.
