Relationship of serum angiotensin converting enzyme level and primary hypertension target organ damage
10.3760/cma.j.issn.1008-6315.2013.07.013
- VernacularTitle:血浆血管紧张素转换酶活性与原发性高血压靶器官损伤的关系
- Author:
Hongyan ZHANG
;
Zhitao ZHANG
- Publication Type:Journal Article
- Keywords:
Primary hypertension;
Target organ damage;
Angiotensin conversion enzyme;
Serum angiotensin conversion enzyme level
- From:
Clinical Medicine of China
2013;(7):708-710
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of serum angiotensin converting enzyme (ACE) level and primary hypertension target organ damage.Methods According to target organ damage,essential hypertension patients were divided into 3 groups:primary hypertension with coronary artery disease,primary hypertension with cerebral infarction and primary hypertension with kidney injury.There were 60 subjects in each complication group.There were 60 healthy adults in the normal control group.Serum ACE level was detected and compare among the 4 groups.Results Serum ACE level in normal control group was (21.36 ± 6.86) U/L,while that in primary hypertension with coronary artery disease,primary hypertension with cerebral infarction and primary hypertension with kidney injury were (36.09 ±4.87) U/L,(39.15 ±7.03) U/L and (28.34 ±7.23) U/L respectively.Serum ACE level was higher in each complication group than in normal control group (F =343.997,P ＜ 0.01).In the complication groups,serum ACE level was the lowest in the group of primary hypertension with kidney injury.Conclusion High active ACE is associated with target organ damage in primary hypertension,especially kidney injury.
