Association between plasma homocysteine and high-sensitivity C-response protein in patients with chronic obstructive pulmonary disease
10.3760/cma.j.issn.1008-6315.2013.06.008
- VernacularTitle:慢性阻塞性肺疾病患者血浆同型半胱氨酸与超敏C反应蛋白水平的相关性研究
- Author:
Wei SHEN
;
Xu CAI
;
Jianmin HUO
- Publication Type:Journal Article
- Keywords:
Chronic obstructive pulmonary disease;
Homocysteine;
High sensitivity C-response protein
- From:
Clinical Medicine of China
2013;(6):586-590
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the functions of blood plasma homocysteine (Hcy) and high sensitivity C-response protein (hs-CRP) in the chronic obstructive pulmonary disease (COPD) in pathogenesis plays,and observe whether there was associations with disease severity and the correlations.Methods Forty-one patients with COPD were collected from August 2010 to February 2011,and 35 healthy persons as control group.Blood plasma Hcy,hs-CRP,forced expiratory volume in one second account predicted (FEV1％ predicted),and arterial pressure of oxygen (PaO2,arterial blood gases analysis) were measured in COPD patients and controls.Results Plasma Hcy concentration was (22.07 ± 12.13) μmol/L in COPD patients,but (9.89 ±4.41) μmol/L in controls,there were significant differences between two subjects (t =1.674,P ＜0.01).COPD patients had a higher serum hs-CRP concentration (8.60±3.85) mg/L than control's (4.24 ±0.57) mg/L (t =1.682,P ＜ 0.01).Along the descent of FEV1％ predicted,plasma Hcy and hs-CRP were elevated gradually,both sides show a negative correlation (r =-0.45,-0.49,P ＜ 0.05).And plasma Hcy and hs-CRP present a positive correlation in COPD patients (r =0.68,P ＜ 0.01).Conclusion Plasma Hcy was significantly elevated in COPD patients,positive correlation related to COPD severity and positive correlation related to serum hs-CRP.
