Clinical significance of serum levels of brain-derived neurotrophic factor in vascular cognitive impairment
10.3760/cma.j.issn.1008-6315.2013.06.003
- VernacularTitle:血管性认知障碍患者血清脑源性神经营养因子水平的变化及其临床意义
- Author:
Binbin WANG
;
Shan WANG
;
Xiaona SHENG
;
Liping YANG
;
Guohua ZHANG
- Publication Type:Journal Article
- Keywords:
Vascular cognitive impairment;
Vascular dementia;
Brain-derived neurotrophic factor;
Enzyme-linked immunosorbant assay
- From:
Clinical Medicine of China
2013;(6):568-571
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of brain-derived neurotrophic factor (BDNF) from peripheral serum in patients of vascular cognitive impairment (VCI).Methods Forty VCI subjects (including 10 mild cognitive impairment vascular(MCI-V) and 30 vascular dementia(VD)),and the control group for the same period in 40 healthy persons.Enzyme-linked immunosorbant assay (ELISA) was used to measure the serum levels of BDNF,statistical analysis was performed.Results The peripheral serum levels of BDNF in VCI (0.175 ±0.056) ng/L were lower than those of control group (0.211 ±0.061) ng/L,and there were significant differences (t =-2.752,P ＜ 0.05).The levels of BDNF showed no significant difference between MCI and VD ((0.195 ± 0.067) ng/L vs.(0.168 ± 0.052) ng/L,t =1.310,P ＞ 0.05).But they were both significantly lower than the control group (F =4.590,P =0.013).No significant differences were observed in the levels of BDNF between subcortical small vessel dementia (0.178 ± 0.057) ng/L and big vascular dementia (0.154 ± 0.042) ng/L (t =1.278,P =0.212).Conclusion BDNF participate in pathophysiology of VCI,and the serum levels of BDNF may be a candidate marker for clinical diagnosis of VCI.But serum levels of BDNF could not reflect the severity or the type of the VCI.
