Expression and significance of BCAR1 in endometrial carcinomas

VernacularTitle:乳腺癌抗雌激素药物耐药蛋白基因在子宫内膜样腺癌中的表达及意义
Author: Ailin LI ; Yang LIU ; Boya DENG ; Xinghua BAI ; Guang LI
Publication Type:Journal Article
Keywords: Breast cancer anti-estrogen resistance; Endometrial carcinoma; Estrogen receptor; Progesterone receptor; Immunohistochemistry
From: Clinical Medicine of China 2013;(6):561-564
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression and significance of BCAR1 protein in endometrial carcinoma.Methods The level of BCAR1 was measured by immunohistochemistry in 50 endometrial carcinoma samples and 30 normal proliferative endometrium samples.Estrogen receptor (ER) and progesterone receptor (PR) expression was investigated in endometrial carcinoma samples.Results The level of BCAR1 was higher in endometrial carcinoma than that in normal proliferative endometrium (64.0％ (32/50) vs.40.0％ (12/30) ;x2 =4.364,P =0.037).In endometrial cancer,increased BCAR1 expression was significantly correlated with relatively higher age,poor differentiation,positive expression of ER (x2 =6.272,r =0.354 ; x2 =5.640,r =0.366 and x2 =4.217,r =0.290 ; P ＜ 0.05).Conclusion BCAR1 promote carcinogenesis and positively correlate with poor differentiation and ER status in endometrial carcinoma.