Expression of ERCC1 and TS in non-small cell lung cancer and its relationship with platinum chemosensitivity
10.3760/cma.j.issn.1008-1372.2013.03.008
- VernacularTitle:ERCC1与TS在非小细胞肺癌中的表达及与铂类化疗敏感性的关系
- Author:
Yong CHEN
;
Xiaoyan JIN
;
Yong LIANG
;
Linjun YANG
- Publication Type:Journal Article
- Keywords:
DNA-binding proteins/metabolism;
Thymidylate synthase/metabolism;
Carcinoma,non-small-cell lung/drug therapy;
Cisplatin/therapeutic use
- From:
Journal of Chinese Physician
2013;(3):317-320
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the excision repair cross-complementing gene 1 (ERCC1) and thymidylate of the acid synthase (TS) in non-small cell lung cancer (NSCLC) and its adjacent tissue,and investigate the relationship of the expression of ERCC1 and TS with the clinical characteristics of NSCLC and prognosis for NSCLC individual therapy to provide experimental basis.Methods The protein expression levels of ERCC1 and TS in 50 cases of postoperative NSCLC cancer and adjacent tissue were detected by immunohistochemical method and the relationship among the expression of ERCC1,TS,and overall survival of patients with NSCLC Phase (OS),disease progression time (TTP),the median OS,and median TTP was analyzed.Results (1)There was an obvious difference between the expression of ERCC1,TS in cancer and paraneoplastic tissue of NSCLC,which had statistically significance (64.00％ vs 20.00％,x2 =19.87,P ＜ 0.01 ;48.00％ vs 24.00％,x2 =6.25,P ＜ 0.05) ; (2)The continued investigation in the patients who received postoperative cisplatin or carboplatin chemotherapy showed that the 0S of negative expression of ERCC1 was significantly longer than the positive one (19.10 vs 10.00 months;x2 =8.133,P =0.002),so was median TTP (15.30 vs 9.00 months; x2 =7.410,P =0.003).The median 0S of the negative expression of TS,was significantly longer than the positive one (17.80 vs 11.00 months,x2 =7.001,P =0.008),so was median TTP (11.40 vs 6.80 months; x2 =5.884,P =0.026).Conclusions ERCC1 and TS protein may become sensitive predictors of platinum chemosensitivity for NSCLC patients ; the detection of combined with ERCC1 and TS would contribute to the selection of individualized treatment programs for NSCLC.
