The expression and significance of COX-2 and VEGF in clear renal cell carcinoma
10.3760/cma.j.issn.1008-1372.2013.03.002
- VernacularTitle:肾透明细胞癌中环氧化酶-2与血管内皮细胞生长因子的表达及其相关意义
- Author:
Peng JIN
;
Xia WANG
;
Bin WU
- Publication Type:Journal Article
- Keywords:
Kidney neoplasms/pathology;
Adenocarcinoma,clear cell/pathology;
Cyclooxygenase 2/metabolism;
Endothelial growth factors/metabolism
- From:
Journal of Chinese Physician
2013;(3):293-295
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between vascular endothelial growth factor(VEGF) and cyclooxygenase-2 (COX-2) in clear renal cell carcinoma (CRCC).Methods In 60 cases of CRCC and 10 cases of normal renal tissue,immunohistochemistry was used to examine the expression of COX-2 and VEGF.Results The positive expression rate of COX-2 in CRCC (76.7%) was significantly higher than that in normal renal tissue (20%) (x2 =10.28,P <0.01).The positive expression rate of VEGF in CRCC(73.3%) was significantly higher than that in normal renal tissue (20%) (x2 =8.58,P <0.01).The expressions of COX-2 and VEGF in CRCC were correlated with each other (r =0.469,P <0.01).Conclusions The expressions of COX-2 and VEGF were involved in the pathophysiolical processes of clear renal cell carcinoma.The expression levels of COX-2 and VEGF might be used to evaluate the development of clear renal cell carcinoma.