A study on circadian rhythm of interictal epileptiform discharges in patients with localization related epilepsy

VernacularTitle:局灶性癫痫患者发作间期痫样放电昼夜变化规律的研究
Author: Fang WANG ; Sipei PAN ; Xingzhou LIU ; Mengyang WANG ; He JING ; Jingying HU
Publication Type:Journal Article
Keywords: Interictal epileptiform discharges; Epilepsy; Sleep; Circadian rhythm
From: Chinese Journal of Behavioral Medicine and Brain Science 2013;(5):406-408
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of circadian rhythm on interictal epileptiform discharges in patients with localization-related epilepsy.Methods Patients diagnosed with epilepsy in Sanbo Brain Hospital from January 2011 to January 2012 participated in this study.All patients were subjected to comprehensive evaluation,which included prolonged video-electroencephalogram (EEG),magnetic resonance imaging.Intracranial electrodes,PET,SPECT were also adopted if necessary.Circadian rhythm was divided into four stages:REM,NREM Ⅰ-Ⅱ,NREM Ⅲ-Ⅳ,and waking.The amount and distribution of ⅡD were compared by ANOVA.Results Significant differences in the amount and distribution of ⅡD were found among NREM Ⅰ-Ⅱ,NREM Ⅲ-Ⅳ,REM,and waking.However,no differences in the amount and distribution of ⅡD were noted between NREM Ⅰ-Ⅱ and NREM Ⅲ-Ⅳ as well as between REM and waking.Conclusion The amount of ⅡD is higher in NREM than in REM and waking;thus,NREM is more sensitive to diagnose epilepsy.The distribution of ⅡD in REM and waking is more restricted than that in NREM.