A auditory-P300 research on male heroin addicts in convalescence and drug craving state

VernacularTitle:康复期男性海洛因依赖者听觉P300电位与毒品渴求状态研究
Author: Qian GUO ; Haifeng JIANG ; Hong CHEN ; Jiang DU ; Jijun WANG ; Min ZHAO
Publication Type:Journal Article
Keywords: Heroin dependence; Auditory P300; Evoked potential; Drug craving state
From: Chinese Journal of Behavioral Medicine and Brain Science 2013;(5):397-399
CountryChina
Language:Chinese
Abstract: Objective To explore the auditory P300 potentials in rehabilitated male patient of heroin addicts (MPHD),as well as the change of P300 amplitude in the drug craving state.Methods Rehabilitated MPHD patients (n =20) and healthy controls (n =20) underwent standard auditory P300 test.Only the patient group completed auditory P300 test after viewing neutral video and drug craving video respectively.Results Rehabilitated MPHD patients showed reduction of P300 amplitude (Cz:(2.72 ± 1.90) μV vs (3.99 ± 1.74) μV ; Pz:(4.48 ± 1.87) μV vs (5.61 ± 1.39) μV ; P ＜ 0.05) than that of healthy controls in standard auditory P300 test.Patients who had been successfully induced by drug craving video demonstrated higher P300 amplitude (Pz:(5.00± 1.68) μV vs (4.19 ± 1.62) μV; P＜0.05) after viewing drug craving video than that of viewing neutral video.Conclusion MPHD patients have cognitive impairment in their rehabilitation period;and P300 index can partially reflect the attention change in patients' drug craving state.