Expression and clinical significance of serum levels of TGF-β1 and TNF-α in patients with hypertensive disorder complicating pregnancy
10.3760/cma.j.issn.1008-6706.2013.14.026
- VernacularTitle:妊娠期高血压疾病患者血清转化生长因子β1和肿瘤坏死因子-α的表达及临床意义
- Author:
Jianhua CHEN
;
Xiaoyan WANG
;
Huamei ZHANG
;
Li MAO
;
Baoxia YANG
- Publication Type:Journal Article
- Keywords:
Hypertension,pregnancy-induced;
Transforming growth factor-β1;
Tumor necrosis factor-alpha
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(14):2144-2146
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and clinical significance of serum levels of transforming growth factor-31 (TGF-β1) and tumor necrosis factor-alpha(TNF-α) in patients with hypertensive disorder complicating pregnancy(HDCP).Methods The serum levels of TGF-β1 and TNF-αin 50 cases with HDCP and 30 cases of normal third trimester pregnant women(control group) were detected by ELISA.50 cases with HDCP were divided into gestational hypertension group,mild preeclampsia group and severe preeclampsia group according to the severity of HDCP.Results The serum levels of TGF-β1 and TNF-α in HDCP patients were significantly higher than the control group (t =13.283,13.607,all P ＜ 0.05).The serum levels of TGF-β1 and TNF-α gradually increased with the aggravating of HDCP disease,the serum levels of TGF-β1 and TNF-αwere significantly different among the three subgroups of HDCP(P ＜ 0.05).The correlation analysis showed that the serum levels of TGF-β1,TNF-α were positively correlated with the severity of HDCP (r =0.575,0.512,all P ＜ 0.05),there was significantly positive correlation between the serum TGF-β1 and TNF-α(r =0.515,P ＜0.05).Conclusion The serum levels of TGF-β1 and TNF-α were high in the HDCP patients,the high levels of TGF-β1 and TNF-α can reflect the changes and development of HDCP disease.The abnormal levels of TGF-β1 and TNF-α may be associate with dysfunction of trophoblast cell.
