Changes and clinical significance of serum human cartilage glycoprotein-39, osteopontin and rheumatoid factor in patients with rheumatoid arthritis

Deting ZHANG; Jing YU

白话标题:类风湿关节炎患者血清人软骨糖蛋白39、骨桥蛋白、类风湿因子水平变化及意义
作者: Deting ZHANG ; Jing YU
出版类型:Journal Article
关键字: Arthritis,rheumatoid; Human cartilage glycoprotein-39; Osteopontin; Rheumatoid factor
来源: Chinese Journal of Primary Medicine and Pharmacy 2013;20(12):1837-1839
国家China
语言:Chinese
摘要: Objective To explore the changes and clinical significance of serum human cartilage glycoprotein-39(HC gP39),osteopontin (OPN) and rheumatoid factor (RF) in patients with rheumatoid arthritis (RA).Methods Serum HC gP39,OPN levels were measured by ELISA in 98 patients with RA and 98 healthy controls.Serum RF was detected by nephelometric immunoassay.Results The serum HC gP39,OPN and RF levels of RA group were significantly higher than the healthy control group (t =20.25,32.71,36.34,all P ＜ 0.01),and serum HC gP39,OPN and RF levels in active phase patients were higher than the inactive phase patients (t =24.22,45.62,50.15,all P ＜0.01).The levels of serum HC gP39,OPN increased gradually with the increase of the staging severity(F =18.48,12.36,all P ＜0.05).The serum level of RF was positively correlated with the levels of HC gP39,OPN in patients with RA (r =0.682,0.656,all P ＜ 0.01),the serum level of HC gP39 was positively correlated with the level of OPN (r =0.608,P ＜ 0.01).Conclusion The HC gP39,OPN and RF reflect situation of RA patients and have close relationship with the clinical progression of RA,which can be used as one of important indexes to judge RA activity and different staging.