The clinical effect of different dose dexamethasone on acute low-frequency sensorineural hearing loss

Jun LIN

白话标题:不同剂量地塞米松治疗急性低频下降型感音性聋疗效比较
作者: Jun LIN
出版类型:Journal Article
关键字: Deafness; Auditory threshold; Dexamethasone
来源: Chinese Journal of Primary Medicine and Pharmacy 2013;20(12):1832-1834
国家China
语言:Chinese
摘要: Objective To compare the clinical effect of different dose dexamethasone on acute low-frequency sensorineural hearing loss (ALHL).Methods 266 cases with ALHL were randomly divided into treatment group (136 cases) and control group (130 cases).On the basis of the comprehensive treatment,the treatment group received dexamethasone 40mg/d intravenous infusion,the control group was given dexamethasone 20mg/d.The treatment effect,average hearing threshold and recurrence were compared between the two groups.Results In the treatment group,the cure rate was 30.8％ (42/136),the effective rate was 50.0％ (78/136),invalid rate was 19.2％(36/136),the total effective rate was 80.8 ％.In the control group,the cure rate was 26.1％ (34/130),the effectiverate was 52.2％ (68/130),the invalid rate was 21.7％ (28/130),the total effective rate was 78.3％,the total effective rate between the two groups had no statistically significant difference (x2 =0.14,P ＞ 0.05).After treatment,125Hz,500Hz band,the average hearing threshold between the two groups had statistically significant differences (P ＜0.05).19 patients relapsed (19/120) in treatment group,the control group had a recurrence of 8 patients(8/102),the recurrence rate between the two groups had statistically significant difference (t =2.241,P ＜ 0.05).Conclusion Dexamethasone has good effect in treatment of ALHL.Small dose dexamethasone can reduce the recurrence rate and has no serious complications.