Effect of combining loop electrosurgical excision procedure and recombinant human interferon α2b suppository in treatment of cervical intraepithelial neoplasia
10.3760/cma.j.issn.1008-6706.2013.11.003
- VernacularTitle:宫颈环形电切术联合重组人干扰素α-2b栓治疗宫颈上皮内瘤变
- Author:
Yitong HUANG
;
Shaohua TANG
;
Xiaohui KE
;
Feng YE
;
Chenxiang PAN
- Publication Type:Journal Article
- Keywords:
Loop electrosurgical excision procedure;
Interferon alfa-2b suppository;
Cervical intraepithelial neoplasia;
Human papillomavirus
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(11):1606-1608
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of combining loop electrosurgical excision procedure (LEEP) and recombinant human interferon α2b (rhIFNα-2b) suppository in treatment of cervical intraepithelial neoplasia (CIN).Methods Prospective,random and control study was conducted in 82 patients with CINⅠ-CINⅢ.Before canting out LEEP to these patients,all women were performed HPV DNA detection by the method of Hybri Max.Among these patients,41 patients were assigned to the studying group,in which the patients were given rhIFNα-2b suppository for three courses of treatment after LEEP.The other 41 patients who carried out LEEP simply were assigned to the control group.Liquid-based ThinPrep cytology test (TCT) and HPV DNA were examined in the sixth and twelfth month after treatment.Results In the studying group,the cure rate was 90.2％ when LEEP ended six months,and the cure rate was 100.0％ when LEEP ended twelve months.In the control group,the cure rate was 43.9％ when LEEP ended six months,and the cure rate was 61.0％ when LEEP ended twelve months.In the sixth and twelfth month after LEEP,the difference was significant when we compared the cure rate between the two groups (x2 =19.93,19.89,all P ＜ 0.05).Conclusion The clinical effect of combining LEEP and rhIFNα-2b suppository is better than LEEP in treatment of CIN.The method can remove or destroy the cervical lesions effectively and inhibit HPV replication and spread of HPV infection.
