Influence of atorvastatin on inflammatory mediators in patients with chronic renal failure combined anemia
10.3760/cma.j.issn.1008-6706.2013.13.003
- VernacularTitle:阿托伐他汀对慢性肾衰并贫血患者微炎性反应的影响
- Author:
Yanyan ZHANG
;
Xiaodong ZHANG
;
Ying LI
;
Hui LI
- Publication Type:Journal Article
- Keywords:
Kidney failure;
chronic;
Atorvastatin;
Anemia;
C-Reactive protein;
Interleukin 6;
Tumor necrosis factor-alpha;
Renal dialysis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(13):1926-1927
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the influence of atorvastatin on inflammatory mediators in patients with chronic renal failure combined anemia.Methods 120 patients with chronic renal failure combined anemia were selected and randomly divided into two groups.The patients in control group underwent regular maintenance hemodialysis(MHD),while the patients in observation group received MHD combined with atorvastatin.Comparison was made between two groups in the aspect of inflammatory mediators and clinical effect of anemia after 3 months.Results After three months treatment,TC,TG,LDL-C,BNP,hs-CRP,IL-6,TNF-α,were significantly decreased after treatment in observation group (P ＜ 0.05),which was (3.41 ± 1.24) mmol/L,(1.35 ± 0.58) mmol/L,(1.63 ± 0.83) mmol/L,(2.61 ±0.69)mmol/L,respectively and they were significantly improved than those in control group after treatment (P ＜ 0.05).The prescribed erythropoietin-stimulating agent dose in observation group was significantly lower than that in the control group(P ＜ 0.05).Conclusion Atorvastatin could lead to lower micro-inflammation and reduce the dosage of erythropoietin-stimulating agent.
