The mechanism of the cerebral protective effect of erythropoietin and angiotensin receptor blocker
10.3760/cma.j.issn.1008-6706.2013.10.001
- VernacularTitle:促红细胞生成素和血管紧张素受体拮抗剂对脑保护作用的机制探讨
- Author:
Huili LIU
;
Lizhen LIANG
;
Chunli WU
- Publication Type:Journal Article
- Keywords:
Erythropoietin;
Angiotensin receptor blocker;
Reperfusion injury
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(10):1441-1443
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of erythropoietin(EPO) and angiotensin receptor blocker on the expression of eNOS and Bcl-2 after cerebral ischemia.Methods The model of focal cerebral ischemia was made by occluding middle cerebral artery(MCA) for 2h and reperfusing for 48h in healthy Sprague-Dawley rats.The rats received EPO 3 000u · kg-1 · d-1 or valsartan 40mg · kg-1 · d-1 by intraperitoneal injection just before the beginning of reperfusion and after reperfusion.The expression of eNOS and Bcl-2 was detected.Results Compared with ischemia group,Bcl-2 and eNOS expressions in EPO-treated group and EPO-ARB treated group were significantly increased (P ＜ 0.05).eNOS expression in ARB-treated group was significantly increased (P ＜ 0.05),Bcl-2 expression was up-regulated,but it had no significant difference.Conclusion EPO had protective effects on cerebral ischemia-reperfu-sion injury in rats,which partially mediated by up-regulating of Bcl-2 and eNOS expression.Angiotensin receptor blocker had protective effects on cerebral ischemia-reperfusion injury in rats,which partially mediated by up-regulating of eNOS expression.
