Comparative analysis of CEA、 CA19-9、 CA72-4 in different pathologic types of gastric cancer
10.3760/cma.j.issn.1008-6706.2013.12.015
- VernacularTitle:癌胚抗原、癌相关糖类抗原19-9、72-4在不同病理分型胃癌患者血清中的含量分析
- Author:
Haiying YU
;
Wenhui LYU
;
Yunxia HAO
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Carcinoembryonic antigen;
CA-19-9 antigen;
CA-72-4 antigen
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(12):1796-1798
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare and analyze the changes of CEA,CA19-9,CA72-4 in different pathologictypes of gastric cancer.Methods 93 patients with gastric cancer were divided into different groups according to the histological types,pathologic types and TNM staging.The levels of CEA,CA19-9,CA72-4 of the patients were measured,then the results were compared and analyzed.Results The level of serum tumor marker of the moderately differentiated group was obviously higher than that of well-differentiated group(P ＜ 0.05),while the level of serum tumor marker of the poorly differentiated group was obviously higher than that of moderately differentiated group (P ＜ 0.05).The differences of levels of CEA,CA19-9,CA72-4 between the well-differentiated group,moderately differentiatedgroup and poorly differentiated group were statistically significant(F =61.433,57.882,125.547,all P ＜ 0.05).The differences of levels of CEA,CA19-9,CA72-4 between patients of TMN Ⅰ stage,TMN Ⅱ stage,TMN Ⅲ stage,TMN Ⅳstage were statistically significant(F =189.624,95.236,80.342,all P ＜ 0.05).The difference of serum tumor marker between different histological groups was not statistically significant (all P ＞ 0.05).Conclusion The concentration of serum CEA,CA19-9,CA72-4 will be higher if the gastric tumor is poorly differentiated or invades deeply,but the concentration of serum tumor has nothing to do with the histological types of the tumor.
