Observation on pioglitazone combined with repaglinide for treatment of external insulin antibody positive patients with type 2 diabetic nephropathy

VernacularTitle:吡咯列酮联合瑞格列奈治疗外源性胰岛素抗体阳性的2型糖尿病肾病观察
Author: Zhimei LIU
Publication Type:Journal Article
Keywords: Diabetic nephropathy; Insulin antibodies; Pioglitazone; Repaglinide
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(9):1326-1328
CountryChina
Language:Chinese
Abstract: Objective To observe the efficacy of pioglitazone combined with repaglinide in the treatment of external insulin antibody (IAb)-positive patients with type 2 diabetic nephropathy.Methods 44 cases with IAb positive diabetes nephropathy were divided into the treatment group (22 cases) and control group (22 cases).The treatment group moved gradually insulin to pioglitazone 15 mg once daily add repaglinide 1 mg three times daily oral and gradually adjustment dose.The control group continued to use insulin treatment,a total of 12 weeks.Before and after treatment,blood sugar,blood fat,glycosylated hemoglobin,etc were detected.Results Mter treatment,the blood glucose,glycosylated hemoglobin,urine albumin and urine creatinine ratio of the treatment group were significantly decreased (all P ＜ 0.01),the above indicators had statistically significant differences compared with the control group at the same period (P ＜ 0.05).Conclusion Pioglitazone combined with repaglinide is an effective method for treatment of IAb positive type 2 diabetic nephropathy.