Effect of enalapril combined with folate acid on endothelial function and urine microalbumin in patients with hypertension
10.3760/cma.j.issn.1008-6706.2013.12.005
- VernacularTitle:依那普利联合叶酸对高血压患者血管内皮功能及尿微量白蛋白的影响
- Author:
Yunfei SHAO
;
Ming LI
;
Xiaofeng WU
;
Huizhi DING
;
Zhijun LU
- Publication Type:Journal Article
- Keywords:
Hypertension;
Enalapril;
Folate acid;
Homocysteine
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(12):1771-1773
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of enalapril combined with folate acid on endothelial function and urine microalbumin(UMA) in patients with hypertension.Methods 120 patients with hypertension were randomly divided into two groups:control group (n =60) was given enalapril 10.0mg/d,observation group (n =60) received enalapril 10.0mg + folic acid 0.4mg/d.The total treatment period was 8 weeks.Blood pressure,plasma homocysteine (Hcy),flow mediated dilation (FMD) and UMA were examined.Results The efficacy of pressure releasinghad no significant difference between two groups.Hcy[(10.2 ± 5.8) μmol/L vs (16.6 ±-8.1) μmol/L,t =3.641],FMD[(14.8 ±5.4)％ vs (8.2±3.5)％,t =7.325] and UMA[(14.8 ±5.4)mg/L vs (31.6 ±9.5)mg/L,t =8.221] of two groups were significantly different after treatment.Conclusion Combination therapy of enalapril and folate acid can decrease plasma Hey and UMA,restore vascular endothelium function in patients with hypertension.
