Observation on gemcitabine plus cisplatin combined with hyperthermia in the treatment of recurrent and metastatic ovarian cancer

VernacularTitle:吉西他滨加顺铂联合腹腔温热化疗治疗复发转移性卵巢癌疗效观察
Author: Wu ZHANG ; Hongyu SUN ; Jianhua WANG
Publication Type:Journal Article
Keywords: Ovarian neoplasms; Hyperthermia,Induced
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(9):1294-1295
CountryChina
Language:Chinese
Abstract: Objective To observe the clinical efficacy of gemcitabine plus cisplatin combined with hyperthermia in the treatment of recurrent metastatic ovarian cancer.Methods 26 patients with advanced metastatic ovarian cancer were given intravenous gemcitabine,cisplatin CHPP treatment.The efficacy and adverse reactions were observed.Results After chemotherapy,complete remission(CR) 5 patients and partial remission(PR) 14 cases,stable (SD) 5 cases,progress(PD) 2 cases,the effective rate was 73.7％.Conclusion Therapy combined with chemotherapy can be used to enhance the cytotoxicity of chemotherapeutic drugs to increase the permeability of drugs on cancer,can improve survival and quality of life of patients,especially for middle and late advanced metastatic ovarian cancer,the clinical effects are particularly obvious.