Impact of different dose dexmedetomidine on postoperative acute agitation after pediatric sevoflurane anesthesia
10.3760/cma.j.issn.1008-6706.2013.10.031
- VernacularTitle:不同剂量右旋美托咪啶对小儿七氟烷麻醉术后反应的影响
- Author:
Jingyun LI
;
Yongjian FU
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
Sevoflurane;
Postoperative complications;
Anesthesia
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(10):1508-1510
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of different dose dexmedetomidine on reducing agitation after sevoflurane anesthesia in patients underwent repair of indirect inguinal hernia.Methods 105 cases of ASA Ⅰ ～ Ⅱ received operation with inhalation of 3％ sevoflurane to induce anesthesia,and then randomly divided into three groups,35 cases in each group.The control group injected with 0.9％ sodium chloride,observation 1 group injected dexmedetomidine 0.15μg/kg,observation 2 group injected dexmedetomidine 0.30μ g/kg.Then placed oropharynx airway ventilation,caudal block.Anesthesia was maintained with 1.2％ sevoflurane,maintain its independent ventilation.Hemodynamic and respiratory changes of the children were recorded.Time to eye opening(TEO) at the end of anesthesia was also recorded.Results Three groups of children had similar operation process.TEO of the control group was (8.45 ± 4.02) min,observation 1 group was (9.23 ± 5.03) min,observation 2 group was (10.81 ± 4.06) min (t =1.23,1.64,all P ＞ 0.05).The incidence rate of agitation of the control group was 42.8％,that in the observation 1 group and observation 2 group was 20％,8.6％.Observation 1 group was significantly lower than that of control group (x2 =3.72,P ＜ 0.05),observation 2 group was significantly lower than that of control group and observation 1 group (x2 =5.14,4.27,all P ＜ 0.05).Conclusion The dose of dexmedetomidine 0.3 μg/kg administered after induction of anesthesia could reduce the postsevoflurane agitation in children and have no adverse effects.
