Effect of interferon combined with golden bifid in the treatment of infantile rotavirus enteritis
10.3760/cma.j.issn.1008-6706.2013.10.017
- VernacularTitle:干扰素联合双歧三联活菌治疗轮状病毒肠炎疗效观察
- Author:
Ying HUANG
- Publication Type:Journal Article
- Keywords:
Rotavirus enteritis;
Children;
Interferon;
Bifiolobigen;
Immune function
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(10):1479-1480
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect of interferon and Jinshuangqi in the treatment of infantil rotavirus enteritis and its effect on immune function.Methods 70 infantil rotavirus enteritis children met inclusion criteria were randomly divided into observation group (n =35) and control group (n =35).Both groups were given conventional treatment,the control group was given Jinshuangqi,the observation group was given interferon on the basis of control group.The two groups had been treated for 7d.The symptoms were observed.Serum immunoglobulin and T lymphocyte before and after treatment were detected,and the clinical efficacy was evaluated.Results The total effective rate of the observation group and the control group was 91.43％,77.14％,the difference was statistically significant(x2 =8.468,P ＜0.05).Antidiarrheal time of observation group and control group was (35.3 ± 11.2) d,(48.6 ± 15.6) d respectively,the difference was statistically significant (t =6.952,P ＜ 0.01).After treatment,IgG,IgA,IgM,CD3,CD4,CD8,CD4/CD8 in the observation group were (5.55 ± 3.58) g/L,(0.46 ± 0.05) g/L,(0.93 ±0.36) g/L,(63.4 ± 7) ％,(44.8 ± 6.4) ％,(25.2 ± 3.5) ％,(1.68 ± 0.20),those in the control group were (4.53 ±3.02)g/L,(0.36 ±0.04) g/L,(0.76 ±0.31)g/L,(62.1 ±6.7)％,(39.7 ±6.1)％,(30.3 ±4.2)％,(1.22 ± 0.25) respectively.The differences of IgG,IgA,IgM,CD4,CD8,CD4/CD8 between two groups were statistically significant(t =3.856,3.117,3.069,3.135,3.111,3.646,all P＜0.05).Conclusion Combined treatment with interferon and Jinshuangqi have exact clinical efficacy,can synergistically improve the immune fimction,restore the cellular and humoral immune,adjust the balance of intestinal flora,build a non-immune gut defense barrier,which is worthy of clinical application in the treatment of infantil rotavirus enteritis.
