The correlation analysis of TNF-α expression and renal damage in gestational hypertension patients

VernacularTitle:妊娠高血压患者血清肿瘤坏死因子-α与肾脏损伤的相关性研究
Author: Xiuai LI ; Aixin YAN
Publication Type:Journal Article
Keywords: Hypertension,pregnancy-Induced; TNF-α
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(9):1347-1348
CountryChina
Language:Chinese
Abstract: Objective To research and analyze the correlation of TNF-αexpression and renal damage in gestational hypertension patients.Methods 60 patients with gestational hypertension were selected as study group.Meanwhile,59 healthy pregnant women were selected as control group.The TNF-α expression and renal function were tested and analyzed.Results The TNF-α expression in study group was (24.7 ± 5.6)μg/L,(12.1 ± 8.2)μg/L in control group (P ＜ 0.05).The serum creatinine in 29 patients in the study group was (317 ± 24) μmol/L,TNF-α (26.9± 1.6)μg/L.The serum creatinine in other 31 patients was (153 ± 18)μmol/L,TNF-α (21.7 ± 2.1)μg/L.The serum creatinine in control group was (56 ± 19) μmol/L,TNF-α (10.3 ±4.1) μg/L.There was a positive correlation between TNF-α expression and serum creatinine.Conclusion The TNF-α expression may be positively correlate with renal damage in gestational hypertension patients.