Clinical observation of valsartan in combination with amlodipine in therapy of essential hypertension together with the impact on red cell distribution width
- VernacularTitle:缬沙坦联合氨氯地平治疗原发性高血压的疗效观察及对红细胞分布宽度的影响
- Author:
Deyong HU
;
Jiashuai WANG
;
Dan HE
;
Guomiao LI
;
Dongmin SHAO
- Publication Type:Journal Article
- Keywords:
Valsartan;
Amlodipine;
Hypertension;
Therapeutic effectiveness;
Red blood cell distribution width
- From:
Chinese Journal of Postgraduates of Medicine
2012;(z2):32-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic effectiveness of valsartan in combination with amlodipine in therapy of essential hypertension and the consequent changes in red cell distribution width (RDW).Methods One hundred and ten patients of hypertension were selected,then randomly divided into treatment group (56 cases) and control group (54 cases).Valsartan and amlodipine were given to the treatment group,while the control group taking amlodipine only.Bp and RBC were carried out before and after treatment.Results Antihypertensive effect of the treatment group were statistically significant compared with the control group (P ＜ 0.05).The consequent RBC,Hct and Hb,RDW level of treatment group decreased dramatically compared with the control group (P ＜ 0.01 or ＜ 0.05).Conclusions Valsartan in combination with amlodipine in ther apy of hypertension is a prospective combination which achieves superior blood pressure control,low level of RDW and blood viscosity,as a result reducing the incidence of cardiovascular events.
