Correlated Study of CRP、IL-12 and Insulin resistance in Gestational Diabetes Mellitus
- VernacularTitle:CRP和IL-12与妊娠期糖尿病胰岛素抵抗的相关性研究
- Author:
Aihong LIU
;
Meilin XIE
;
Xuan SUN
- Publication Type:Journal Article
- Keywords:
Gestational Diabetes Mellitus;
Insulin resistance;
CRP;
IL-12
- From:
Chinese Journal of Postgraduates of Medicine
2012;(z2):22-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective to investigate the relationship between CRP,IL-12 and gestational diabetes mellitus.Methods Fifty normal pregnant women (NGT group) and forty with GDM (GDM group) were enrolled in the study.The serum IL-12、fasting blood sugar、CRP were mesured respectively.Results GDM fasting blood glucose,fasting insulin,insulin resistance index (IRI),CRP,IL-12 were higher than those in the control group [(4.95 ± 0.76 vs 4.57 ± 0.58) mmol/L,(13.65 ± 1.74 vs 8.78 ± 1.65) uIU/ml,(2.91 ± 1.05vs 1.72 ± 0.87),(5.56 ± 1.24 vs 3.25 ± 1.13) mg/L,(71.47 ± 4.35 vs 56.03 ± 4.06) PG,/ml,P ＜ 0.05),the results of single factor analysis of CRP showed a positive correlation with IRI (r =0.865,P ＜ 0.05),IL-12 was positively correlated with IRI (r =0.913,P ＜ 0.05).Conclusions Our study show inflammatory cytokins take part in the genesis of gestational diabetes.Serum levels of IL-12 and is one factor in pathogensis of GDM.
