Myloied derived suppressor cells and cancer
10.3760/cma.j.issn.1673-422X.2013.05.004
- VernacularTitle:髓系抑制性细胞与肿瘤
- Author:
Lijuan SHAO
;
Ruoyu WANG
;
Tingting WU
;
Yong ZHAO
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Myeloid cells;
Myloied derived suppressor cells;
Targeted therapy
- From:
Journal of International Oncology
2013;(5):332-335
- CountryChina
- Language:Chinese
-
Abstract:
Myeloid derived suppressor cells(MDSCs) are a subpopulation of immunosuppressive innate immune cells derived from bone marrow stem cells,which negatively regulate immune response in tumor progression.MDSCs have a powerful suppressive function and significant heterogeneity.They can modulate innate and adaptive immune responses through a variety of mechanisms to promote the development of tumor,and also facilitate angiogenesis and metastasis of tumor via non immunologic mechanisms.In recent years,as increasingly mature research for the differentiation,proliferation and suppressive function of MDSCs,the derived researches of MDSC-targeted tumor immunotherapy will finally contribute to increasing the efficiency of vaccine and tumor therapy in the future.
