Polymorphisms of metabolic enzymes in relation to susceptibility of lung cancer
10.3760/cma.j.issn.1673-422X.2013.04.010
- VernacularTitle:代谢酶基因多态性与肺癌易感性
- Author:
Qi WANG
;
Weiguo HU
;
Qibin SONG
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Polymorphism,genetic;
Disease susceptibility
- From:
Journal of International Oncology
2013;(4):274-278
- CountryChina
- Language:Chinese
-
Abstract:
It is proved that there are significant differences in individual susceptibility to lung cancer.Genetic polymorphisms of several enzymes involved in the detoxification and biotransformation might be related to the lung cancer susceptibility.Cytochromes P450,N-acetyltransferases,microsomal epoxide hydrolase,NQO1 are the most frequently investigated genes in recent years.All theses genes appear to be the candidates for lung cancer susceptibility genes.The studies of the relationship between polymorphisms of metabolic enzymes and lung cancer susceptibility will help to find useful biomarkers.An improved understanding of genetic polymorphisms may help to identify individuals who are at increased risk for lung cancer and decrease the incidence of lung cancer.
