Roles of AMP-activated protein kinase in cerebral ischemia
10.3760/cma.j.issn.1673-4165.2013.03.011
- VernacularTitle:腺苷酸活化蛋白激酶在脑缺血中的作用
- Author:
Zhenqing GONG
;
Yongjiu WANG
;
Yan CHENG
- Publication Type:Journal Article
- Keywords:
AMP-Activated Protein Kinases;
brain ischemia;
Energy Metabolism;
Neuroprotective Agents
- From:
International Journal of Cerebrovascular Diseases
2013;(3):216-221
- CountryChina
- Language:Chinese
-
Abstract:
Adenosine monophosphate-activated protein kinase (AMPK) is a serine/threonine protein kinase,which is a energy regulation switch in the cells of the body.In the case of nutritional deficiencies and ischemia,AMPK system is activated as the metabolism and stress signal transduction component to regulate the expression of downstream target proteins.After acute ischemic stroke,AMPK is activated and aggravates neuronal apoptosis,and giving AMPK inhibitor may reduce cerebral ischemic injury.The activation of AMPK after stroke may result in the upregulation of brain-derived neurotrophic factor expression and the activation of endothelial nitric oxide synthase,and they play the protective roles for neuronal regeneration and repair.This article reviews the advances in research on the roles of AMPK in experimental cerebral ischemia.
