Anti-tumor effect of piplartine and its mechanism
10.3760/cma.j.issn.1673-422X.2013.04.006
- VernacularTitle:荜茇明碱抗肿瘤作用及其机制
- Author:
Zhifeng YAO
;
Jianxin YAO
;
Yongbiao LIU
- Publication Type:Journal Article
- Keywords:
Antineoplastic agents;
Apoptosis;
Reactive oxygen species;
Piplartine
- From:
Journal of International Oncology
2013;(4):259-263
- CountryChina
- Language:Chinese
-
Abstract:
Piplartine is an alkaloids/amide component of Piper species,having diverse pharmacological and biological activities.Recent studies have indicated that piplartine has inhibitory effects on several kinds of tumors and is a kind of potential antitumor drugs.It can inhibit the proliferation of tumor cells,cause cell cycle arrest and induce apoptosis.More investigations suggest that targeting the reactive oxygen species(ROS) stressresponse pathway is closely related to its antitumor activity.
