Advances on heme oxygenase-1 on angiogenesis of tumors
10.3760/cma.j.issn.1673-422X.2013.04.005
- VernacularTitle:血红素加氧酶-1在肿瘤新生血管化中的作用
- Author:
Jingjing CAI
;
Qianli MENG
;
Haike GUO
- Publication Type:Journal Article
- Keywords:
Neovascularization,pathologic;
Neoplasms;
Heme oxygenase-1
- From:
Journal of International Oncology
2013;(4):255-259
- CountryChina
- Language:Chinese
-
Abstract:
Studies show that heme oxygenase-1 (HO-1) can promote the tumor neovascularization via interacting with angiogenic factors,such as vascular endothelial growth factor (VEGF) and stromal cell-derived factor-1.On the other hand,HO-1 may suppress angiogenesis in tumors via inhibiting the transcription of NF-кB.In a word,HO-1 may participate in the pathophysiological process of tumor angiogenesis,and may be a new target for cancer treatment.
