Mel-18 gene and neoplasms
10.3760/cma.j.issn.1673-422X.2013.04.002
- VernacularTitle:Mel-18基因与肿瘤
- Author:
Xuezong XU
;
Jingyan CAO
;
Yan YU
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Genes,tumor suppressor;
Mel-18
- From:
Journal of International Oncology
2013;(4):246-249
- CountryChina
- Language:Chinese
-
Abstract:
Mel-18 gene is one of the core members of the PcG (polycomb group) family,which plays an important role in embryogenesis,cell growth and proliferation and self-renewal of stem cells.Mel-18 gene expressing abnormally has been related to human tumorigenesis,development process.Mel-18 serves as a tumor suppressor gene and inhibits tumor growth through transcriptional repression of Bmi-1 and c-myc.Mel-18 expression is decreased at transcriptional and translational levels in most human cancers including breast cancer,prostate cancer,and gastric cancer and other tumors.Mel-18 is expected to become a prognostic marker for human cancers.
