MICA gene and tumors
10.3760/cma.j.issn.1673-422X.2013.04.001
- VernacularTitle:MICA基因与肿瘤
- Author:
Yunyan WANG
;
Zongyuan XU
;
Junsong MENG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Tumor escape;
Major histocompatibility complex class Ⅰ chain related gene A
- From:
Journal of International Oncology
2013;(4):243-246
- CountryChina
- Language:Chinese
-
Abstract:
Major histocompatibility complex class Ⅰ chain related gene A(MICA) is located within the MHC class Ⅰ region of chromosome 6,including six exons.The MICA locus encodes membrane-bound polypeptides,similar with the classic class Ⅰ molecules,including three extracellular domains (α1,α2 and α3),a transmembrane domain,and a cytoplasmic tail,but is not associated with β2-microglobulin.MICA gene is expressed on endothelial cells,epithelial cells as well as most epithelial tumor cells surfaces,and are involved in the process of cell differentiation,proliferation and infiltration in a variety of tumor cells.Soluble MICA (sMICA) can be used as the prognosis predicting factor for some tumors.MICA gene plays an important role in the pathogenesis of a variety of malignant tumors,which might bring new ideas in prevention and treatment for malignant tumors.
