Pulmonary surfactant-A and immune response in lung
10.3760/cma.j.issn.1673-4408.2013.03.008
- VernacularTitle:肺表面活性物质相关蛋白A与肺部免疫应答的关系
- Author:
Xia HUANG
- Publication Type:Journal Article
- Keywords:
Pulmonary surfactant;
Immune function;
Inflammation
- From:
International Journal of Pediatrics
2013;(3):240-242
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary surfactant is a complex mixture of lipids and surfactant proteins (SP) lining the alveolar surface.In addition to the well established ability of the surfactant system to reduce alveolar surface tension and thereby prevent collapse of the alveoli on expiration,it is also involved in pulmonary host defence.Surfacant protein-A (SP-A),one of the most abundant SP,can deal with various pathogens,using a range of innate immune mechanisms,and links innate immunity with adaptive immunity that includes modulation of dendritic cell function and helper T cell polarization.Surfactant-replacement or increasing SP-A generation might be efficacious for the treatment of inflammatory and infectious diseases in the lung.
