Advances of the relationship of asthma and store-operated calcium
10.3760/cma.j.issn.1673-4408.2013.03.006
- VernacularTitle:哮喘与钙库操纵钙离子内流的关系研究进展
- Author:
Li WANG
- Publication Type:Journal Article
- Keywords:
Store-operated calcium;
Asthma;
Stromal interaction molecule 1;
Calcium release-activated calcium channel protein
- From:
International Journal of Pediatrics
2013;(3):234-236
- CountryChina
- Language:Chinese
-
Abstract:
As one of the chronic diseases,asthma,plays a serious impact on human daily life.Asthma in children has showed an increasing trend in recent years,but the mechanisms of asthma are not yet clear.Studies have found that store-operated calcium entry(SOCE) plays an important role in the physiological activity of the body.The enhanced SOCE activity can promote cell growth,proliferation,and migration of a variety of cell types.SOCE important molecules STIM1 and ORAI1 may be involved in the asthmatic airway occurrence of hyperresponsiveness and airway remodeling,and closely to the asthmatic development.
