Expression of CD117, CD34 and Ki-67 in gastric stromal tumors and their significances

VernacularTitle:CD117、CD34、Ki-67在胃间质瘤中的表达及其意义
Author: Peng LI ; Wentong XU
Publication Type:Journal Article
Keywords: Gastrointestinal stromal tumors; Immunohistochemical; CD117; CD34; Ki-67
From: Cancer Research and Clinic 2013;(6):393-395
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinicopathologic and immunohistochemical features of gastric stromal tumors.Methods A total of 105 cases with gastric stromal tumors were included in the study.The expression of cluster of differentiation 117 (CD117),cluster of differ entiation 34 (CD34),smooth muscle actin (SMA),S-100 protein and Ki-67 in gastric stromal tumors specimens was detected by immunohistochemistry.The clinico-pathologic features of gastric stromal tumors were also analyzed.Results Of 105 gastric stromal tumors specimens,90 were positive for CD117 [85.7 ％ (90/105)],98 positive for CD34 [93.3 ％ (98/105)],21 positive for SMA [20.4 ％ (21/105)],60 positive for Ki-67 [56.1％ (60/105)],13 positive for S-100 [12.4 ％ (13/105)].Conclusion Combined detection of CD117 and CD34 can improve the diagnostic accuracy of gastric stromal tumors.The expression of Ki-67 can be used as a prognostic parameter for gastric stromal tumors as it is correlated with tumor size,risk and mitotic.