Expressions of ER, PR and CerbB-2 in papillary thyroid carcinoma and their clinical significances
10.3760/cma.j.issn.1006-9801.2013.05.017
- VernacularTitle:雌、孕激素受体及人类表皮生长因子受体-2在甲状腺乳头状癌中的表达及其临床意义
- Author:
Ying JIN
;
Ying WANG
;
Feng LI
;
Changzheng WANG
;
Zhiying SI
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Immunohistochemistry;
Receptors,estrogen;
Receptors,progestin;
CerbB-2
- From:
Cancer Research and Clinic
2013;(5):339-341
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expressions of ER,PR and CerbB-2 in human papillary thyroid carcinoma,and their correlation with the clinical features.Methods The expressions of ER,PR and CerbB-2 were detected by immunohistochemistry in 89 papillary thyroid carcinoma samples and 13 nodular goiter samples.Results In papillary thyroid carcinoma samples,ER,PR and CerbB-2 were detected for 50.56 ％(45/89),43.82 ％ (39/89),24.72 ％ (22/89),respectively.In nodular goiter,ER,PR and CerbB-2 were detected for 15.38 ％ (2/13),7.69 ％ (1/13),0,respectively,there were significant differences between the two groups (x2 =5.649,P=0.017,x2 =6.211,P=0.013,x2 =4.097,P=0.043).The positive rates of PR were 56.26 ％(26/46) in without lymph node metastasis,compared with those lymph node metastasis 30.2 3％ (13/43) were significantly higher,the difference was statistically significant (x2 =6.239,P =0.012).Conclusion The expressions of ER,PR and CerbB-2 are significant higher in papillary thyroid carcinoma.The detection of ER,PR and CerbB-2 might be helpful for early diagnosis and prognosis of papillary thyroid carcinoma.
