Gemcitabine transcatheter arterial heated chemotherapy combined with carboplatin transcatheter arterial chemoembolization for primary hepatocellular carcinoma
10.3760/cma.j.issn.1006-9801.2013.05.014
- VernacularTitle:吉西他滨热化疗灌注联合卡铂肝动脉化疗栓塞治疗原发性肝癌临床研究
- Author:
Junpeng LUO
;
Hongtao HU
;
Quanjun YAO
;
Yanli MENG
;
Chenyang GUO
;
Hailiang LI
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Chemotherapy,cancer,regional perfusion;
Chemoembolization,therapeutic
- From:
Cancer Research and Clinic
2013;(5):328-331
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the therapeutic effect of thermochemotherapy infusion combined with chemoembolization in the treatment of primary hepatocellular carcinoma.Methods Ninty six patients with hepatic carcinoma were randomly diveded into two groups.In A group,the patients underwent thermochemotherapy infusion combined with chemoembolization.In B group,chemotherapy infusion was done combined with chemoembolization.Before the therapy,the basic examinations of patients were improved,including liver function,renal function,immune function.At the same time,each patient was performed with enhanced CT scan.Three days and a month after treatment,main outcome measures,containing liver function,renal function,and immune function were examined,the volumes of tumor were measured on CT.Repeat treatment were performed between four and six weeks.Follow-up was performed after the third treatment,patients survival periods were observed.Results A and B groups of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were higher than pre-treatment after 3 days (all P ＜ 0.05),but the ALT and AST in group B were both higher than those in group A (P =0.001,P =0.002),there were no changes after 30 days.No significant difference of renal function were found in the both groups.In the A group,the total efficiency was 75.00 ％ (36/48),and that of the B group was 39.58 ％ (19/48),showing statistically significant difference (P ＜ 0.01).In the A group,the immunity state of patients were improved after treatment.In the A group,the median survival time was 24.0 months (95 ％ CI was 20-29 months).In the B group,the median survival time was 18.9 months (95 ％ CI was 18-20 months).There was significant difference between the two groups (P ＜ 0.01).Conclusion The gemcitabine transcatheter arterial heated chemotherapy combined carboplatin with transcatheter arterial chemoembolization is effective treatment for primary hepatocellular carinoma.
