Research on Effective Component Group Identification from Traditional Chinese Medicine Formula based on Entity Grammar Systems

VernacularTitle:基于实体语法系统的中药方剂有效成分群辨识方法研究＊
Author: Ji LUO ; Yun WANG ; Yanjiang QIAO
Publication Type:Journal Article
Keywords: Entity grammar systems; traditional Chinese medicine formula; effective component group
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2013;(3):482-488
CountryChina
Language:Chinese
Abstract: This study was aimed to explain the relationship between chemical component and therapy objective and to identify effective component group (ECG). The objective of this study is to build a new method to identify the ECG. Traditional Chinese medicine (TCM) formula and one of its treated diseases were selected as the re-search object. The entity grammar systems (EGS) were used as the theoretical framework. A grammatical method for ECG identification was constructed. The component-disease relationship was inferred and the ECG was identi-fied with these inference results. In this paper, 16 compounds which act to 12 proteins in Type 1 diabetes melli-tus (T1D) disease network were identified from Bai-Hu Tang plus Xiao-Ke Fang and 9 chemical compounds were determined as the candidate effective components group. The results indicated that this method can be used to identify ECG and provide a new way to elucidate the molecular mechanism of TCM formula.