Honghua Peng

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"Clinical Research on Mechanism of ""Jia-Jian Xiao-Yao Powder"" Improving Facial Skin Barrier Function of Hormone-dependent Dermatitis Patients"

VernacularTitle:加减逍遥散改善面部激素依赖性皮炎患者皮肤屏障功能的临床研究＊
Author: Honghua PENG
Publication Type:Journal Article
Keywords: "Facial hormone -dependent dermatitis; ""Jia -Jian Xiao -Yao Powder""; skin barrier function; transepidermal water loss; IL-4"
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2013;(3):539-542
CountryChina
Language:Chinese
Abstract: This study was aimed to observe the mechanism of Jia-Jian Xiao-Yao (JJXY) Powder improving facial skin barrier function of the hormone-dependent dermatitis patients. A total of 100 patients were randomly divided into two groups. In the treatment group, 50 cases were orally administered with JJXY Powder. In the control group, loratadine and vitamin EC particles were orally administered to the 50 cases. Thirty days is one treatment course. Changes of transepidermal water loss (TEWL), skin erythema amount and IL-4 were detected in patients of both groups before and after the treatment. The results showed that the clinical efficiency of treatment group and control group was 82.0% and 58.0%, respectively. In the treatment group, the TEWL and skin erythema amount were obviously decreased after the treatment (P < 0.05). In the treatment group, the decreasing range of serum IL-4 was significant compared to control group (P < 0.05). It was concluded that JJXY Powder is one of the effective methods for the treatment of facial hormone-dependent dermatitis. It is able to repair facial hormone-dependent dermatitis in patients with impaired skin barrier function and reduce the amount of skin erythema. The therapeutic mechanism may be related to the regulation of serum IL-4.