Study on the correlation between EGFR-STAT3 signal pathwayand laryngeal papilloma
10.3969/j.issn.1001-1781.2009.18.006
- VernacularTitle:上皮生长因子受体-信号转导与转录激活因子3信号转导通路与喉乳头状瘤的相关性研究
- Author:
Xinhua WANG
;
Jingwu SUN
- Publication Type:Journal Article
- Keywords:
laryngeal papilloma;
signal transduction pathway;
epidermal growth factor receptor;
signal transducer and activator of transcription3
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;(18):832-836
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between the expression of EGFR and STAT3 in human la-ryngeal papilloma and its biological behavior. Method: Reverse transcription polymerasechain reaction(RT-PCR), immunohistochemical staining and Western blot were used to evaluate the mRNA and protein expression of EGFR and STAT3(p-STAT3) in 42 laryngeal papilloma tissues and 15 samples of normal laryngeal tissue, and the rela-tionship between the protein expression of them and clinicpathological parameters was also analysized. Result: The mRNA expression levels of EGFR and STAT3 in laryngeal papilloma tissue were significantly higher than that in normal laryngeal tissue(P<0.05,P<0.01). Protein positive expression of EGFR and p-STAT3 were also detected in a significantly greater proportion of laryngeal papilloma than normal laryngeal tissue by immunohistochemistry and western blot(P<0.01,P<0.05). There was relationship between EGFR and p-STAT3 overexpression in la-ryngeal papilloma(P<0.05). The expression p-STAT3 was correlated with the recurrence and canceration of la-ryngeal papilloma(P<0.05). Conclusion: The EGFR-STAT3 signal transduction pathway may be involved in the pathogenesis of laryngeal papilloma,, and the persistent activation of STAT3 gene plays an important role in the recurrence and canceration of laryngeal papilloma.
