Expression of EMS1 protein and its clinical significance in laryngeal carcinoma
10.3969/j.issn.1001-1781.2009.15.001
- VernacularTitle:EMS1蛋白在喉癌组织中的表达及临床意义
- Author:
Lianhe LI
;
Zhuoli YUE
;
Xiuling FENG
;
Jina LIU
;
Shuhong LIU
- Publication Type:Journal Article
- Keywords:
laryngeal neoplasms;
EMS1 protein;
flow cytometry
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;(15):673-675
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of EMS1 in laryngeal carcinoma and its clinical signifi-cance. Method:The expression of EMS1 protein was measured in 40 samples of, 40 samples of para carcinoma tis-sues (which were near to cutting margin of laryngeal carcinoma tissuse over 0. 5 cm) ,and 20 samples of normal la-ryngeal mucosa as controls by Flow Cytometere( Epics-XL Ⅱ ). Results:The quantity and percentage of EMS1 pro-tein expression in laryngeal carcinoma tissues was significantly higher than those in para carcinoma and in normal laryngeal mucosa tissues respectively(P<0. 05). There was no significant expression difference between the para carcinoma tissues and normal laryngeal mucosa tissues. There were positive correlation between the expressions of EMS1 protein and metastasis, pathological grade and clinical stage in laryngeal carcinoma. But there were not rela-tionship with patients' clinical classification, tumor size, smoking history, age and sex. Conclusion: The high ex-pression of EMS1 may contribute to the carcinogenesis and development of laryngeal carcinoma. The expression of EMS1 protein is an important index of judging differentiation, infiltration, metastasis and staging of laryngeal car-cinoma.
