Preventive effects of pueraria on presbycusis in rats
10.3969/j.issn.1001-1781.2009.15.011
- VernacularTitle:葛根对老年性聋大鼠的治疗作用
- Author:
Wangyan CHEN
;
Qi YAO
;
Weihong LIU
;
Bibo ZHANG
;
Ying WANG
;
Bo LIU
- Publication Type:Journal Article
- Keywords:
pueraria;
presbycusis;
rat
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;(15):703-705
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the preventive effects of Pueraria on presbycusis in rats. Method:Thirty-two 24-26 month old Wistar rats were randomly divided into four groups, and were treated with different dosages of Pueraria (1,2,4,0 g·kg~(-1)·d~(-1)) seperately for 4 weeks. Auditory brainstem response (ABR) was used to de-tect the change of hearing threshold of rats. Hemorheological items of rats were checked in each group. Result: Compared with control group,the hearing threshold and hemorheological items of rats was significantly improved after treated with Pueraria(P<0. 05). In addition, 2 g/(kg·d) was found to be the best dosage of Pueraria for rats, which can achieve ideal effect with minimum side effect. Conclusion:Pueraria could improve tiny circulation, has good preventive effect on presbycusis of rats.
