Expression and significance of SP-A in nasal mucosa of allergic rhinitis and nasal polyp
10.3969/j.issn.1001-1781.2009.14.007
- VernacularTitle:肺表面活性蛋白A在变应性鼻炎鼻黏膜及鼻息肉组织中的表达及意义
- Author:
Yuqin DENG
;
Jingjing ZUO
;
Zezhang TAO
;
Yonggang KONG
;
Bokui XIAO
- Publication Type:Journal Article
- Keywords:
allergic rhinitis;
nasal polyp;
surfactant protein A;
immunohistochemistry;
immunofluorescence
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;(14):642-645
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Surfactant protein A (SP-A) is protein that appears to play an important role in mammalian first-line host defense. The objective of this study was to immunolocalize SP-A in human sinonasal tissue. Method:Eleven cases of allergic rhinitis, fifteen cases of polyp and seven cases of normal middle turbinate were studied with immunohistochemistry and immunofluorescence method to detect the expression of SP-A. Result:The expression of SP-A in allergic rhinitis and polyp were dramatically higher than that in controls(P<0.05), and there was no remarkable difference in the expression of SP-A between allergic rhinitis and polyp(P>0.05). The result demonstrated that SP-A was positivly correlated with eosinophils within the basement membrane of epitheli-um(R=0.81,0.55). In the result of immunofluorescence, there was significantly higher expression SP-A in nasal mucosa of allergic rhinitis and nasal polyp than that in control group(P<0.05). Conclusion:SP-A is likely to play key roles in the inflammatory reaction process of allergic rhinitis and polyp. Its secretion in the upper airway indicates that future studies may allow manipulation of this protein and development of novel treatments for sinonasal pathology.
