Combination of fMRI and DTI in the Assessment of Cortical Visual Impairment in the Children with Periventricular Leukomalacia
10.3969/j.issn.1005-5185.2009.06.001
- VernacularTitle:脑室旁白质软化症患儿脑性视觉损伤的fMRI和DTI研究
- Author:
Na LIU
;
Guoguang FAN
;
Bing YU
;
Songbai LI
- Publication Type:Journal Article
- Keywords:
periventricular leukomalacia;
functional MRI;
cerebral visual injury
- From:
Chinese Journal of Medical Imaging
2009;(6):401-405
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To investigate fMRI and DTI in the assessment of cortical visual impairment in children with periventricular leukom-alacia ( PVL).Materials and Methods: Twenty-four children with PVL were enrolled.Meanwhile,24 age-matched normal controls were recruited for comparison.fMRI scan was performed using a 3.0T MR scanner.Data analysis was performed by statistical parametric mapping software (SPM2).Activated voxels were identified in both groups,t test was used for statistical analysis.DTI was performed by MedlNRIA software and DTI color maps were created from fractional anisotropy (FA) values and the three vector elements,FA values on diffusion tensor color maps were compared between the patients and the controls.AH the FA values of these WM fibers were analyzed by paired t test.The correlation was calculated between FA values and activated voxels of visual cortex for PVL children using SPSS10.0.Results: In all 24 normal children,the maximum response of blood oxygen level-dependent (BOLD) signal was located in the primary visual cortex ( PVC).However,some of the 24 cases of PVL had deviated activation.The active voxels of patients in visual cortex were less than that of controls.All 24 cases of PVL showed a significant mean FA reduction in ICPL and PTR in comparison to the ipsilateral regions of healthy controls.The significantly positive correlation was shown between FA values and activated voxels of visual cortex for PVL children.Conclusion:fMRI and DTI play an important role in the assessment of cortical visual impairment in children with PVL.
