A Comparison Study of Using Sildenafil on Persistent Pulmonary Hypertension of the Newborn
10.3969/j.issn.1000-3606.2009.08.001
- VernacularTitle:西地那非治疗新生儿持续肺动脉高压比对研究
- Author:
Gang QIU
;
Yucai ZHANG
;
Qiwei HUANG
;
Qunfang RONG
;
Xiaohui GONG
;
Min HUANG
- Publication Type:Journal Article
- Keywords:
sildenafil;
persistent pulmonary hypertension;
newborn;
cardiac function
- From:
Journal of Clinical Pediatrics
2009;(8):701-704
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect and safety of sildenafil on persistent pulmonary hypertension of the newborn (PPHN). Also compared the effect of sildenafil with tolazoline and milrione. Methods Forty five neonates with PPHN were recruited from January 2005 through October 2008 in NICU, 25 males and 20 females. The median gestational age was (39.3 + 2.4) weeks, the median birthweight was (3 114.0±10.2) g, and the median age were (13.0±0.8) hours. The patients were randomly assigned to receive sildenafil, tolazoline and milrione therapy. The pulmonary artery pressure (PAP) was measured by echocardiography. Results Thirty patients were cured, 6 patients were improved and 9 patients were of no effect. The total effective rate was 80%. There was no statistical difference among sildenafil, tolazoline and milrione. The PAP decreased when the patients were treated with sildenafil, tolazoline and milrione. No side effects happened in all patients treated with the three drugs. Conclusions Sildenafil is an effective and safe drug to reduce PAP of PPHN and it also help to improve cardiac function.