Expression of filamin A in invasive breast carcinoma and its significance
10.3781/j.issn.1000-7431.2009.07.012
- VernacularTitle:细丝蛋白A在浸润性乳腺癌中的表达及意义
- Author:
Yanping WU
;
Jingbin LI
;
Ruijing ZHAO
;
Xiaoling WANG
;
Baoen SHAN
;
Tienian ZHU
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Microfilament proteins;
Immunohistochomistry;
Neoplasm invasiveness
- From:
Tumor
2009;(7):659-662
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between the expression of filamin A (FLNa) and clinical pathological features in invasive breast carcinoma. Methods:The expression of FLNa was measured by immunohistochemistry and flow cytometry in 46 cases of invasive breast carcinoma. Results:The expression level of FLNa was increased in poorly differentiated invasive breast carcinoma. There were significant differences between well-moderately differentiated and poorly differentiated groups (P<0.05). The expression level of FLNa in invasive breast carcinoma with lymph node metastasis was higher than that in non-metastasis group (P<0.05). Conclusion:The level of FLNa expression correlated with invasion and metastasis of invasive breast carcinoma. FLNa can be used as an assistant marker for prediction of breast carcinoma prognosis and has the potential to be a new target for cilinical therapy.
