Expression of aldehyde dehydrogenase 1 in breast cancer and its clinical significance

VernacularTitle:乙醛脱氢酶1蛋白在乳腺癌中的表达及临床意义
Author: Ling ZHOU ; Pei YU ; Jianfeng WANG ; Keying SONG ; Aifang JIANG ; Hong XU ; Ke LI
Publication Type:Journal Article
Keywords: Breast neoplasms; Stem cells; Aldehyde dehydrogenase 1; Immunohistochemistry
From: Tumor 2009;(7):663-667
CountryChina
Language:Chinese
Abstract: Objective:The purpose of this study is to investigate the expression of tumor stem cell marker aldehyde dehydrogE-nase 1 (ALDH1) in breast cancer and its clinical significance. Methods:The expression of ALDH1 protein was examined by immunohistochemical staining in 92 breast cancer tissues. The correlation analysis and diseasE-free survival analysis of patients was evaluated based on the clinical follow-up data. Results:Expression of ALDH1 protein had a significant correlation with progesterone receptor (PR) and cerb-B2 (P<0.05), but had no significant correlation with age, tumor size, clinical staging, and lymph node metastasis (P>0.05). The 2-year diseasE-free survival rate of AlDH1-positive patients was lower than that of ALDH1-negative patients (P<0.05). ALDH1-positive patients, who received CEF regimen chemotherapy and hormone therapy, had lower 2-year diseasE-free survival rate than that of ALDH1-negative patients (P<0.05). Conclusion:The decreased diseasE-free survival rate of ALDH1-positive patients is related with drug resistance. ALDH1 could be used as an independent factor for predicting the prognosis of breast cancer.