Influence of Xiaokekang on Renal Function in Diabetic Nephropathy Rats

VernacularTitle:消渴康对糖尿病肾病大鼠的治疗作用
Author: Dexian JIA ; Xiaomei JI ; Qian WANG ; Yu HAO ; Qiuxia ZHANG ; Xinlou CHAI ; Yingshu LIU ; Pengfei TIAN ; Weilian SU ; Liwei REN
Publication Type:Journal Article
Keywords: Xiaokekang; diabetic nephropathy; rat
From: Chinese Journal of Experimental Traditional Medical Formulae 2009;(7):57-59
CountryChina
Language:Chinese
Abstract: Objective:To observe the changes of glyeemia, urine protein, serum creatinine, blood urea nitrogen and glycosylated hemoglobin in diabetic nephropathy rats and treating effects of Xiaokekang. Methods: Streptozotocin (STZ) was abdominally administered and was feeded by high lipid diet to establish diabetic nephropathy model in rats. Animals were divided into three groups: model group, Xiaokekang treatment group and normal group. Changes in glycemia, serum lipids, serum creatinine, blood urea nitrogen were measured at the 8th, 12th and 16th week after STZ injection. Glycosylated hemoglobin was measured at the 16th weeks after STZ injection. Results: Glycemia, serum lipids, serum creatinine were higher at the 8th, 12th and 16th week compared with normal group. Serum creatinine was higher at the 12th and 16th week, and glycosylated hemoglobin was also highter than that of the normal group. Xiaokekang reduced these changes. Conclusion: Xiaokekang can reduce glycemia, serum lipids and protect renal function.