Anti-tumor Effect of Phellinus Linteus and Coriolus Versicolor Capsule on S180 sarcoma and H22 hepatoma in mice
10.3969/j.issn.1005-9903.2009.07.031
- VernacularTitle:桑黄云芝胶囊对小鼠肉瘤S180及肝癌H22移植性肿瘤生长的抑制作用
- Author:
Kunxing LI
;
Xueping ZHU
;
Hailin ZHANG
;
Ke NIE
;
Wei GUO
- Publication Type:Journal Article
- Keywords:
Phellinus Linteus and Coriolus Versicolor Capsule;
sarcoma S180;
hepatoma H22;
vascular endothelial growth factor (VEGF);
survival time
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2009;(7):83-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the anti-tumor effect of Phellinus Linteus and Coriolus Versicolor Capsules (PLCVC) in S180 sarcoma and H22 hepatoma animal models in mice. Methods: The sarcoma S1180 and hepatoma H22 models were established in mice. After 12 days of treatment, the animals were killed, and the subcutaneous sarcoma were separated and weighted. The levels of vascular endothelial growth factor(VEGF), CD4 and CD8 of S180 tumor tissue were investigated by immunohistochemical method. KM mice were intraperitoneal injected with H22 hepatoma cells, and treated with different experimental drugs. The survival time was observed and recorded, and life-prolongation rate was calculated. Result: PLCVC could inhibit the growth of S180 and H22 tumor, and inhibit the expression of VEGF, improve the expression of CD4 and CD8. The survival time of the mice treated by PLCVC were significantly longer than the untreated group. Conclusion: PLCVC can inhibit the growth of tumour, the mechanism is partially related to inhibiting angiogenesis and improving the immunological function.
