The Pathological Study on Effective Compounds of TongMai in Treating MsPGN in Rats
10.3969/j.issn.1005-9903.2009.07.021
- VernacularTitle:通脉新复方对系膜增殖性肾炎病理学改变的影响
- Author:
Mingping LIU
;
Zhaosheng HUANG
;
Nizhi YANG
;
Pingqing WEI
;
Qingguang WU
- Publication Type:Journal Article
- Keywords:
Effective compounds of Tongmai;
MsPGN;
Pathological injury
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2009;(7):54-57
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the therapeutic effects of effective compounds which were extracted from TongMai. Methods: SD rats experimential model with MsPGN were induced by subcutaneously injection rabbit anti-rat thymocyte serum(ATS) and forced swim. The rats were respectively ig with different dose(1.2,0.6,0.3 g'kg-1) of effective compound of TongMai for 4 weeks. Then the proliferative degree of mesangium was examined by HE stain, PAS stain and immunfluorescent respectively. Mesagium area proportion in glomerular capillaries area was calculated using image analyzing system. The expression of PCNA in the glomeruli was examined by immunohis to chemistry. Results: The effective compounds of TongMai can control the hyperplasia of the glomemlar mesangial cells (GMG)and the mainifold of the mesangial matrix, and prevent the deposit of IgG in mesangium. The proportions in glomerular capillaries area in model control group were significantly higher than that in the treatment groups; The express of proliferative cell nuclear antigen (PCNA) were ascended either. Conclusion: The effective compound of TongMai can improve the damage s of pathology in glomerular.
